Breast Cancer

2-methoxyestradiol downregulated cyclin D1 and cell cycle progression

Published in Cancer Weekly, May 10th, 2005

2-Methoxyestradiol (2-ME2) was suggested to downregulate cyclin D1 and cell cycle progression.

"We studied the effects of 2-ME2 and 16alpha-hydroxyestrone (16alpha-OHE1), two metabolites of estradiol (E-2) on DNA synthesis, cell cycle progression and cyclin D1 protein levels in estrogen receptor-positive MCF-7 cells. E-2 and 16alpha-OHE1, stimulated DNA synthesis, and 2-ME2 inhibited the stimulatory effects of these agents. E-2 and 16alpha-OHE1, stimulated the progression of cells from G₁ to S phase and this effect was attenuated by 2-ME2," scientists reported in the Journal of Molecular Endocrinology.

"Western blot analysis showed...

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Source: Cancer Weekly (2005-05-10)

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