Protein Kinase C

Integrin expression examined, nature of stimulation defined

Published in Cancer Weekly, May 10th, 2005

According to recent research from the United States published in the Journal of Biological Chemistry, deletion of mouse embryo fibroblast N-acetylglucosaminyltransferase V (GnTV) stimulates alpha5beta1 integrin expression mediated by the protein kinase C signaling pathway.

"An N-linked glycan often increased during oncogenic transformation contains beta(1,6)-linked GlcNAc, synthesized by GnTV. The progression of polyoma middle T-antigen oncoprotein-induced mammary carcinomas in GnTV-null mice was significantly retarded compared with that observed in wild-type mice. The matrix adhesion of mouse embryonic fibroblasts (MEF) from GnTV-null and wild-type mice was...

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Source: Cancer Weekly (2005-05-10)

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