Breast Cancer

YB-1 expression in breast cancer may indicate chemoresistance

Published in Cancer Weekly, May 10th, 2005

Y-box binding protein 1 (YB-1) expression in breast cancer may indicate chemoresistance.

According to recent research from Singapore, "The Y-box binding protein 1 regulates gene expression through transcription and translation. YB-1 has been shown to be associated with up-regulation of P-glycoprotein (Pgp), an ATP-binding transporter involved in multidrug resistance. In this study, we determined the prognostic significance of YB-1 and its relationship with Pgp in patients with breast cancer."

"YB-1 and Pap expression were evaluated by immunohistochemistry in resected specimens of infiltrative ductal breast cancers from 99 patients and 57 patients...

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Source: Cancer Weekly (2005-05-10)

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