Cancer Drugs

Betulinic acid facilitated anticancer drug-induced apoptosis

Published in Cancer Weekly, May 10th, 2005

Researchers examined how betulinic acid (BetA) works with anticancer drugs to induce cancer cell apoptosis.

"We previously described that BetA, a naturally occurring pentacyclic triterpenoid, induces apoptosis in tumor cells through the mitochondrial pathway. Here, for the first time, we provide evidence that BetA cooperated with anticancer drugs to induce apoptosis and to inhibit clonogenic survival of tumor cells. Combined treatment with BetA and anticancer drugs acted in concert to induce loss of mitochondrial membrane potential and the release of cytochrome c and Smac from mitochondria, resulting in activation of caspases and apoptosis," scientists in Germany...

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Source: Cancer Weekly (2005-05-10)

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