Apoptosis

Inhibitor of apoptosis protein studied, nature of inhibition defined

Published in Cancer Weekly, May 17th, 2005

A study from the United States has documented that the X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 using two binding sites.

"The XIAP uses its second baculovirus IAP repeat domain (BIR2) to inhibit the apoptotic executioner caspase-3 and -7. Structural studies have demonstrated that it is not the BIR2 domain itself but a segment N-terminal to it that directly targets the activity of these caspases. These studies failed to demonstrate a role of the BIR2 domain in inhibition," wrote F.L. Scott and colleagues, Burnham Institute.

"We used site-directed mutagenesis of BIR2 and its linker to determine the mechanism of...

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Source: Cancer Weekly (2005-05-17)

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