Apoptosis

Alpha-helical structure in p53 peptides determined mechanism of cell death

Published in Cancer Weekly, May 17th, 2005

The alpha-helical structure in p53 peptides might help determine whether cell death occurs through necrosis or apoptosis.

According to a study from the United States, "Peptides derived from the N-terminal and C-terminal regions of the p53 tumor suppressor protein, linked to the membrane transduction domain of Antennapedia, have both been found to have significant cytotoxic effects selectively in human cancer cells."

"However, the N-terminal and C-terminal p53 peptides apparently display very different mechanisms for their anticancer effects. These differential effects can be attributed to dissimilar abilities to form distinctive 3-dimensional...

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Source: Cancer Weekly (2005-05-17)

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