Published in Cancer Weekly, May 17th, 2005
"The phosphatidylinositol 3' kinase (P13'K) pathway, which regulates cell survival, is antagonized by the PTEN tumor suppressor. The regulation of PTEN is unclear," said R.H. Kim and colleagues at the Ontario Cancer Institute.
"A genetic screen of Drosophila gain-of-function mutants identified DJ-1 as a suppressor of PTEN function. In mammalian cells, DJ-1 underexpression results in decreased phosphorylation of PKB/ Akt, while DJ-1 overexpression leads to hyperphosphorylation of PKB/Akt and increased cell survival," the researchers reported.
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