Renal Cancer
Naked DNA congregates in mammalian kidneys upon systemic administration
Published in Cancer Weekly, May 17th, 2005
"A major challenge for gene therapy is to be able to deliver efficiently the gene of interest to specific cell types. Here we describe a safe and simple effective naked DNA gene delivery method, via inferior vena cava ( IVC) injection, to the recipient's kidneys. It was further demonstrated that gene expression was concentrated in the proximal tubular epithelial cells of the cortico-medullary region of the kidney," scientists in Singapore report.
"Confocal microscopy analyses demonstrated the presence of the exogenous DNA in the renal cell membrane 10 min postgene delivery....
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Source: Cancer Weekly (2005-05-17)
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