Skin Cancer
p73 gene selected as anti-tumoral target of the RAR retinoid tazarotene
Published in Cancer Weekly, May 17th, 2005
"Tazarotene, a member of the new class of acetylenic retinoids, has been shown to be effective in the treatment of several hyperproliferative skin diseases, including non-melanoma skin cancer. Its effectiveness is thought to rely on the ability to activate retinoic acid receptors beta and gamma and to induce a number of downstream anti-proliferative genes. Here, we show that the p53-related gene p73 is a target of tazarotene," investigators in Italy reported.
"Indeed, tazarotene modulates the expression of the p73 gene in immortalized keratinocyte cell lines by...
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Source: Cancer Weekly (2005-05-17)
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