Cancer Weekly

Finance - Diagnostics/genomics company reports revenues of $1.2M in Q1

Finance - Drug-development company reports Q1 net loss of $5,113,000

Finance - GVAX maker reports a net loss of $29.3 million in first quarter

Finance - GenVec reports first-quarter 2005 financial results

Finance - Genomics-based pharma reports Q1 net loss of $19.4 million

Finance - Immunotherapy company reports first-quarter net loss of $8.4 million

Finance - Maker of DNA-based therapeutics reports Q1 revenue of $5.5 million

Finance - Men's health company reports Q1 net loss of $9.1 million

Finance - Pharma company focused on cancer and atherosclerosis reports financials

Finance - Pharmaceutical company reports 58% increase in first quarter revenue

Finance - Pharmaceutical company reports financial results for first quarter 2005

Finance - THALOMID maker reports record operating performance in Q1

Gastric Cancer -  PIK3CA dysregulated in gastric tumors

Gastric Cancer - Screening of DNA copy-number aberrations in gastric cancer conducted

Gastroenterology - Adenovirus-based MUC1 gene transfer stops pancreatic cancer cell proliferation

Gastroenterology - Case of small cell carcinoma of the common bile duct reported

Gastroenterology - STI571 inhibited interaction between c-KIT and heat shock protein 90

Gene Research - Developer of monoclonal antibody therapies forms collaboration with MedImmune

Gene Silencing - Antisense thioredoxin may stop tumor angiogenesis by altering HIF-1

Gene Silencing - STAT3 knockdown shutters breast tumor formation in murine models

Graft-Versus-Host Disease - Aspirin-triggered lipoxin A(4) has a protective effect on GvHD cellular dynamics

Gynecology - Recent studies add new data to gynecology research

HIV/AIDS-Related Lymphoma - Primary mediastinal large B-cell lymphoma diagnosed in HIV-infected patient

Head & Neck Cancer - Cathepsin B RNA inhibitors may prevent oral cancer invasion

Head & Neck Cancer - Impact of CT-scan and of MRI on nasopharyngeal carcinoma treatment examined

Head and Neck Cancer - Recent findings in head and neck cancer provide new insights

Health Promotion - Pathologists association releases email reminder Web site for screening test

Heat Shock Protein - Heat shock protein 70 examined, role in clonogenicity of leukemic cells revealed

Hematology - Researchers detail new studies and findings in the area of hematology

Hepatitis A - Hepatitis A vaccinations seen as necessary for all foodservice workers

Human Papillomavirus - Factors cause variable reflex high-risk HPV testing results in women with ASCUS

Human Papillomavirus - HPV genotype distribution determined among women in Western Australia

Human Papillomavirus - Men need to be included in HPV prevention efforts

Human T-cell Leukemia Virus - Susceptibility to leukemia virus envelope-mediated fusion investigated

Imidazole - NAMI-A exhibited antimetastatic effects on KB tumor cells

Immunology - New roles of neuropeptide cortistatin in the immune system and cancer determined

Immunology - Research in immunology provides new insights

Inhibitors - Histone deacetylase inhibitors affected DNA methylation

KSHV Diagnostics - PCR detects KSHV in transbronchial biopsies in HIV patients with Kaposi sarcoma

Kidney Cancer - Human kidney injury molecule-1 identified as tissue and urinary tumor marker

Kidney Cancer - Renal cell carcinoma assessed using contrast-enhanced gray-scale ultrasound

Leukemia - AML1-ETO fusion protein upregulated TRKA mRNA expression

Leukemia - Fluoroquinolone resistance of Escherichia coli in neutropenic leukemia

Leukemia - Gene mutations in TRAIL receptors were absent in chronic myelogenous leukemia

Leukemia - Giving children access to drug trials is crucial, clofarabine approval shows

Leukemia - Recurrent abnormality in chronic and acute leukemia fused PCM1 to JAK2

Lipid Bilayers - Amphiphilic copolymers studied, ability to disturb lipid bilayers clarified

Lipid Research - Xanthohumol cancels lipid metabolism in hypoxic tumor cells

Liver Cancer - Antiangiogenic gene therapy treats tumors in hepatocellular carcinoma models

Liver Cancer - Genes involved in fenretinide-induced apoptosis identified

Liver Cancer - Histopathology of liver cancers examined

Liver Cancer - Molecular mechanisms in hepatocellular carcinoma development reviewed

Liver Cancer - Multidetector computed tomography detected different manifestations of HCC

Liver Cancer - Neoadjuvant chemotherapy used to prepare patients before liver resection

Liver Cancer - Preoperative treatment for hepatocellular carcinoma with radiation succeeded

Liver Cancer - Prognosis of hepatocellular carcinoma after hepatectomy evaluated in patients

Liver Cancer - Serological markers of liver cancer determined

Liver Cancer - Treatment of hepatocellular carcinoma reviewed

Liver Cancer Therapy - Right inferior phrenic artery inflow can impair HAIC distribution

Lung Cancer - ACS cited as mechanism responsible for tumor recurrence and progression

Lung Cancer - Apoptosis of human lung carcinoma cells induced by hybrid liposomes

Lung Cancer - Lung cancer death rates by smoking compared between the U.S. and Japan

Lung Cancer - Research on lung cancer pathogenesis updated

Lung Cancer - Tc-99m-MIBI tumor tissue uptake assessed

Lymphoid Development - Frizzled 9 knock-out mice have abnormal B-cell development

Lymphoma - Follicular lymphoma subgrouping by fluorescence analyzed

Lymphoma - Localized non-Hodgkin lymphoma of the testis studied

Lymphoma - Proto-oncogene MYC broke B cell tolerance

Lynch Syndrome - Check colon tumors for signs of syndrome, study suggests

Melanoma - Melanoma cells express elevated levels of phosphorylated histone H2AX foci

Melanoma - Novel tumor suppressor p33ING2 enhanced UVB-induced apoptosis in human melanoma

Melanoma - Simple calibration method developed for Ru-106-Rh-106 eye applicators

Melanotransferrin - Distribution of transferrin homologue, melanotransferrin examined

Mergers & Acquisitions - Brachytherapy-focused company agrees to acquire wound closure company CP Medical

Metastatic Colorectal Cancer - Pharma companies initiate phase 3 of PACCE study

Multiple Myeloma - Bortezomib injection for treating multiple myeloma gets E.U. marketing approval

Multiple Myeloma - Male donor is significant predictor for survival in unrelated SCT for MM

Mutagenesis - Endothelial cell defects may compromise the value of antiangiogenic therapy

Natural Products - Gac fruit extract diminishes tumor growth and neovascularization

Nervous System - Radiation exposure examined as a nervous system toxin

Neural Stem Cell Research - Tumor cells attract endogenous precursor cells whose presence is antitumorigenic

Neuroblastoma - Gene profiling of high-risk neuroblastoma conducted

Non-Hodgkin Lymphoma - Fifth grader honors terminally ill aunt through school project

Non-Small Cell Lung Cancer - Desired tumor response achieved in phase 2 non-small cell lung cancer trial

Oncogenesis - Fatty acid metabolism regulates cancer cell survive in hypoxic environments

Oncology - Aberrant proteins are a hallmark of primary liver cancer progression

Oncology - Angiogenic growth factor receptors predict poor outcomes from breast cancer

Oncology - Antibody gains rapid access to integrin overexpressed on tumor vessel lumina

Oncology - Antisense oligonucleotide-mediated hTERT inhibition hinders prostate cancer

Oncology - Damaged DNA-binding protein 2 plays a major role in resistance to apoptosis

Oncology - Findings describe new data in oncology research

Oncology - Maspin promotion limits tumor metastasis

Oncology - The PDX-1 gene is an early marker for a variety of human cancers

Oncoproteins - PARP-10 analyzed, transformation inhibition demonstrated

Oral Cancers - Chingwaysan induced apoptosis in human oral cancer cell lines, OC2 and TSCCa

Osteoporosis - Cathepsin K discovery program designates candidate drug

Ovarian Cancer - Agreement signed to evaluate proteomic system for ovarian cancer diagnostics

Ovarian Cancer - Blocking COX-1 slows tumor growth in mice

Ovarian Cancer - Expression of splicing variant in 5'-UTR of human ERCC1 gene not cancer related

Ovarian Cancer - Phase I trial data on topotecan/carboplatin/paclitaxel regimen reported

Pain Medicine - Relevance of opioid tolerance and dependence explored

Pancreatic Cancer - Findings regarding reproductive and menstrual risk factors are inconsistent

Pancreatic Cancer - Genetics of hereditary pancreatic carcinoma analyzed

Pancreatic Cancer - Metal stents are safe and effective for treatment of obstructions

Papillomavirus - Rabbit papillomavirus oncoproteins associated with tumor suppressor

Pathology - Reporting endometrial cells has clinical significance for only for older women

Pediatric Leukemia - CpG islands of p15INK4B gene in childhood acute leukemia were hypermethylated

Personnel - Consultancy names executive vice president and general counsel

Personnel - Dr. CJ Wang joins biopharma as vice president of business development

Personnel - Immunotherapy company names Dr. David Sidransky to scientific advisory board

Personnel - THYMITAQ maker adds three new members to management team

Personnel - Therapeutics company announces promotion

Phosphorylation - Artemis analyzed, phosphorylation in response to DNA damage revealed

Primary Cutaneous Melanoma - Researchers examine expression of ezrin in primary cutaneous melanoma

Prognosticators - Chromogranin A prognosticated hormone-refractory prostate cancer

Prostate Cancer - Activation of p53/p21(Waf1/Cip1) pathway inhibited cell proliferation

Prostate Cancer - European cancer clinic installs linear accelerator for prostate cancer treatment

Prostate Cancer - Heat shock protein expression elevated in aggressive tumors

Prostate Cancer - Microsatellite analysis of specimen identity conducted

Prostate Cancer - Recent advances made in steroidal antiandrogens and 5 alpha-reductase inhibitors

Prostate Cancer - Zoledronic acid mediated ras-independent growth inhibition of prostate cancer

Protein Expression - Esophageal cervical inlet patch studied, protein expression clarified

Protein Expression - Testicular development analyzed, CDK11(p58) expression defined

Protein Interactions - p53-DNA crystal structures analyzed, protein-protein interfaces compared

Proteomics - Researchers describe findings in proteomics studies

Proteomics - Targeted aquaporin-1 gene disruption impairs cell migration and angiogenesis

Pulmonary Medicine - Mutations in Hupki murine fibroblasts resemble those in human lung tumors

Pulmonary Medicine - Repeat pulmonary resection for recurrent lung metastases gave comparable results

RNA Research - Delivery technology achieves tumor knockdown with targeted siRNA

Radiation Therapy - Arsenic trioxide augments effects of radiotherapy on solid tumors

Receptor Studies - Pyrazine-pyridine biheteroaryl obstructs VEGF receptor activity

Rectal Cancer - Critical issues in identification and management of colorectal cancer patients

Rectal Cancer - Effects of irradiation combined with CDDP suppository in rectal tumors examined

Rectal Cancer - IORT increases survival rate in rectal cancer study patients

Rectal Cancer - Serum triglyceride and glucose associated with colorectal cancer

Skin Cancer - Cellular and molecular events led to development of skin cancer

Skin Cancer - Photochemoprevention of ultraviolet B signaling and photocarcinogenesis examined

Skin Cancer - Psychosocial factors of sun protection practices among parents of young children

Skin Cancer - Teenage boys least likely to practice proper sun protection

Squamous Cancer - Status of reduced expression and hypermethylation of APC tumor suppressor gene

Squamous Cancer - T-cadherin negatively regulates cutaneous squamous carcinoma proliferation

St. John's Wort - St. John's wort induced a decrease in plasma concentration of P-glycoprotein

Stem Cell Disorders - Acquired PTPN11 mutations rarely occur in myelodysplastic syndromes and CMLL

Stem Cell Donor Search - Inefficient search process is reason that finding compatible HSC donor fails

Stem Cell Research - Boost HSC decreases donor chimerism/graft dysfunction in PID patients

Stem Cell Research - Company reports on bone marrow tissue repair cell technology

Stem Cell Transplantation - Elevated T-1 cells prior to ASCT increases acute graft-versus-host disease risk

Stem Cell Transplantation - G-CSF affects serum levels of soluble IL-2 receptors following ASCT

Stem Cell Transplantation - HLA-haploidentical nonmyeloablative SCT successful in PBSCT-resistant patient

Stem Cell Transplantation - Outcome not improved with higher-dose therapy to reduce relapse after SCT in AML

Stem Cell Transplantation - Pilocarpine has no benefit for the moderation of oral mucositis during ASCT

Stem Cell Transplantation - Reduced intensity ASCT feasible for low-grade non-Hodgkin lymphoma in elderly

Stem Cell Transplantation - Unmodified AHSCT from KIR ligand-incompatible donors provides long-term efficacy

T-Cell Large Granular Lymphocyte Leukemia - Epitope defined for HTLV env seroreactivity observed in LGL leukemia

Tamoxifen - Methylation rate of the ER beta gene and tamoxifen resistance inversely related

Tamoxifen - Molecular changes associated with agonist activity of hydroxy-tamoxifen

Testicular Cancer - Necrotizing fasciitis found in a patient who was in long-term remission

Therapy - Longicalycinin A reported, role as cytotoxic cyclic peptide revealed

Throat Cancer - Quality of life measures compared for patients with esophageal cancer

Thymosins - Roles of thymosins in cancers and other organ systems studied

Thyroid Cancer - Potential role of tumor macrophages in carcinoma physiology reported

Thyroid Cancer - Sporadic tumors from Ukrainian and French patients compared

Thyroid Cancer - rhTSH aided radioiodine ablation and treatment of differentiated thyroid cancer

Tobacco Use - Smoking-gene interaction related to pancreatic cancer and atherosclerosis

Tobacco Use - Urinary trans, anti-PheT may be biomarker of PAH uptake, metabolic activation

Tumor Markers - Folate receptor expression in cancer determined by radioligand binding assay

Ultraviolet Light - Mutations induced by ultraviolet light

Uterine Cancer - Clomiphene citrate to induce ovulation may increase cancer risk

Virology - New research in the area of virology detailed

Virology - Viral interactions accelerate non-Hodgkin lymphoma progression

Virus Activation - K-Rta essential for lytic viral reactivation and transactivation of viral genes