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Breast Cancer

Soy isoflavone daidzein improved capacity of tamoxifen to prevent mammary tumors

Published in Cancer Weekly, May 24th, 2005

According to recent research published in the European Journal of Cancer, "The aim of this study was to determine how the efficacy of tamoxifen is affected when combined with soy isoflavones. To address this, female Sprague-Dawley rats were placed on diets supplemented with tamoxifen, genistein, daidzein, or a combination of each isoflavone with tamoxifen; a week later mammary tumors were induced by 7,12 dimethylbenzanthracene. The most effective diet was the tamoxifen/daidzein combination."

"It reduced tumor multiplicity by 76%, tumor incidence by 35%, tumor burden by over 95%, and increased tumor latency by 62% compared with positive controls. The...

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