Oncology
Aberrant proteins are a hallmark of primary liver cancer progression
Published in Cancer Weekly, May 24th, 2005
"Chromosome 4q exhibits high frequency of allelic loss in hepatocellular carcinoma (HCC). This study aimed to elucidate the interaction of the frequent aberrant mRNA expression of alpha-fetoprotein (AFP), osteopontin (OPN) and a novel short isoform of annexin A10 (ANXA10S) at 4q in the tumor progression among 294 patients who received surgical resection of unifocal primary HCC," scientists writing in the International Journal of Oncology report.
"AFP overexpression, OPN overexpression and ANXA10S down-regulation correlated with high-grade and high-stage tumors, early tumor...
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Source: Cancer Weekly (2005-05-24)
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