Phosphorylation

Nuclear export of Mdm2 examined, requirement for MdmX phosphorylation shown

Published in Cancer Weekly, June 7th, 2005

A study published from the United States has demonstrated that phosphorylation of MdmX by CDK2/Cdc2(P34) is required for nuclear export of Mdm2.

"Mdm2 and MdmX function as cellular regulators of the p53 tumor suppressor protein. Intriguingly, the activities of these proteins are interdependent; MdmX stabilizes Mdm2, enabling its activities towards p53, but it also requires Mdm2 for its nuclear localization," wrote B. Elias and colleagues, Mt. Sinai School of Medicine.

"Here we demonstrate that via its phosphorylation by CDK2/Cdc2(p34), MdmX regulates nuclear export of Mdm2. Cdc2(p34) phosphorylates MdmX on Ser-96 in vitro. Mutation within this site...

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Source: Cancer Weekly (2005-06-07)

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