Colon Cancer
Microsatellite instability associated with sporadic colon cancer
Published in Cancer Weekly, June 14th, 2005
"Currently, colon cancer is a leading cause of cancer death worldwide. It progresses according to three molecular pathways named suppressor, mutator and methylator," scientists writing in the journal Medicina Clinica reported.
"Microsatellite instability is a hallmark of the lack of reparation, of DNA mismatches and it characterizes a subset of colon tumors (unstable tumors, MSI). MSI-H patients (high degree of microsatellite instability) seem to share clinico-pathological differences with MSS (microsatellite stable) and MSI-L (low degree of microsatellite instability)...
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Source: Cancer Weekly (2005-06-14)
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