Stem Cell Transplantation

Thymic recovery onset/thymic output plateau differentially regulated after SCT

Published in Cancer Weekly, June 14th, 2005

Thymic recovery onset and thymic output plateau is differentially regulated after stem cell transplantation in children.

According to published research from Germany, "Thymus-dependent T-cell regeneration is a major pathway for immune reconstitution after stem cell transplantation in children.

"Therefore, we prospectively assessed T-cell dynamics and thymic function in 164 pediatric patients between 1 and 124 months after transplantation by measuring T-cell receptor recombination excision circles and spontaneous expression of Ki67 in peripheral T-cell subsets."

"We analyzed the effect of recipient age, conditioning regimen, type...

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Source: Cancer Weekly (2005-06-14)

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