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Doxorubicin

Chronic progressive cardiac dysfunction linked to doxorubicin therapy for ALL

Published in Cancer Weekly, June 21st, 2005

Chronic progressive cardiac dysfunction was linked to doxorubicin therapy for childhood acute lymphoblastic leukemia (ALL).

According to a study from the United States, "Cross-sectional studies show that cardiac abnormalities are common in long-term survivors of doxorubicin-treated childhood malignancies. Longitudinal data, however, are rare."

"Serial echocardiograms (n=499) were obtained from 115 doxorubicin-treated long-term survivors of childhood acute lymphoblastic leukemia (median age at diagnosis, 4.8 years; median follow-up after completion of doxorubicin, 11.8 years)," explained S.E. Lipshultz and colleagues, University of Miami.

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