Genetics and Genomics

Archival tissues suitable for study of spatial genome organization

Published in Cancer Weekly, June 28th, 2005

Archival tissues are suitable for use in analysis of human spatial genome organization.

"Sections from archival formalin-fixed, paraffin wax-embedded human tissues are a valuable source for the study of the nuclear architecture of specific tissue types in terms of the three-dimensional spatial positioning and architecture of chromosome territories and sub-chromosomal domains," scientists in Germany explained.

In a study conducted by T. Wiech and coauthors at the University Hospital in Freiburg, "chromosome painting, centromeric, and locus-specific probes were hybridized to tissue microarrays prepared from formalin-fixed paraffin wax-embedded samples...

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Source: Cancer Weekly (2005-06-28)

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