Acute Lymphoblastic Leukemia
Multiple subclones identified in TEL-AML1 at diagnosis
Published in Cancer Weekly, July 5th, 2005
"The TEL/AML1 (ETV6/RUNX1) fusion gene is the most common genetic rearrangement" in pediatric ALL, hematologists in Israel explained. "Although considered to be a low-risk leukemia, it is associated with a relapse rate of 10%-20%."
"The coexistence of different subclones at diagnosis, based on polymerase chain reaction (PCR) studies of IG/TCR gene rearrangement, with differential response to chemotherapy, was recently reported in this subtype of ALL," noted R. Rothman and colleagues at Chaim Sheba...
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Source: Cancer Weekly (2005-07-05)
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