Cancer Vaccine

Cancer immunotherapy based on killing Salmonella-infected tumors

Published in Cancer Weekly, July 5th, 2005

Cancer immunotherapy based on killing of Salmonella-infected tumor cells is showing clinical promise.

"A major obstacle for the development of effective immunotherapy is the ability of tumors to escape the immune system. The possibility to kill tumor cells because they are recognized as infected rather than as malignant could help overcome immune escape mechanisms. Here we report a conceptually new approach of cancer immunotherapy based on in vivo infection of tumors and killing of infected tumor cells," scientists in Italy report.

"Attenuated but still invasive, Salmonella typhimurium can be successfully exploited to invade melanoma...

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Source: Cancer Weekly (2005-07-05)

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