Published in Cancer Weekly, July 19th, 2005
"The protein tyrosine phosphatase (PTEN) gene is an important tumor suppressor mutated in a number of cancers. To date, its growth regulatory properties have been intimately linked to its ability to act as a protein and phosphoinositol phosphatase," investigators in the United States reported.
"Inactivation of the enzymatic activity of PTEN is primarily due to direct mutation of its amino-terminal catalytic domain but approximately 20% of mutations are in the carboxy-terminus, which regulates membrane localization, protein stability, cellular migration and p53...
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