Phosphatase

Novel anti-oncogene discovered

Published in Cancer Weekly, July 19th, 2005

Scientists discovered a novel anti-oncogene in protein tyrosine phosphatase (PTEN).

"The protein tyrosine phosphatase (PTEN) gene is an important tumor suppressor mutated in a number of cancers. To date, its growth regulatory properties have been intimately linked to its ability to act as a protein and phosphoinositol phosphatase," investigators in the United States reported.

"Inactivation of the enzymatic activity of PTEN is primarily due to direct mutation of its amino-terminal catalytic domain but approximately 20% of mutations are in the carboxy-terminus, which regulates membrane localization, protein stability, cellular migration and p53...

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Source: Cancer Weekly (2005-07-19)

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