Published in Cancer Weekly, July 26th, 2005
"Post-translational modifications of proteins have critical roles in many cellular processes because they can cause rapid changes in the functions of preexisting proteins, multiprotein complexes and subcellular structures. Sumoylation, a ubiquitin-like dynamic and reversible post-translational modification system, is an enzymatic cascade leading to the covalent attachment of SUMO to it target proteins."
"This modification involves three steps and different enzymes: SUMO-activating enzyme E1...
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