Endocrinology
Growth factor blockade cuts follicular thyroid cancer metastasis in mice
Published in Cancer Weekly, July 26th, 2005
"Patients suffering from bone metastases of follicular thyroid carcinoma (FTC) have a poor prognosis because of the lack of effective treatment strategies. The overexpression of epidermal growth factor receptor (EGFR) associated with increased vascularity has been implicated in the pathogenesis of FTC and subsequent bone metastases," scientists in the United States report.
"We hypothesized that inhibiting the phosphorylation of the EGFR and vascular endothelial growth factor receptor (VEGFR) by AEE788, a dual tyrosine kinase inhibitor of EGFR and VEGFR, in combination with...
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Source: Cancer Weekly (2005-07-26)
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