Melanoma
Protein amplification in melanoma is possible drug target
Published in Cancer Weekly, July 26th, 2005
Gene amplification is a process that often happens in cancer cells when the normal DNA replication process is altered, causing many copies of the gene to be produced instead of a single copy of a region of a chromosome.
The researchers found that the MITF (microphthalmia-associated transcription factor) master regulator is the target of gene amplification in melanoma. MITF amplification also was more prevalent in metastatic disease and was correlated with decreased overall patient...
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Source: Cancer Weekly (2005-07-26)
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