Oncology
Recombinant CXC chemokine ligand 10 boosts the potency of cisplatin
Published in Cancer Weekly, July 26th, 2005
According to a study from People's Republic of China, "CXC chemokine ligand 10 (CXCL10) is a potent inhibitor of angiogenesis. We wonder whether the combination of CXCL10 with cisplatin would improve the therapeutic antitumor efficacy."
"We evaluated the antitumor activity of the combination therapy in the immunocompetent C57BL/6 and BALB/c mice bearing LL/2 Lewis lung cancer and CT26 colon adenocarcinoma, respectively. Mice were treated with either CXCL10 s.c. at 25 mcg per kg per day once daily for 30 days, cisplatin cycled twice (5 mg/kg i.p. on days 14 and 21 after the...
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Source: Cancer Weekly (2005-07-26)
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