Pediatric Oncology
Pediatric and adult leukemia cells bear distinctly different properties
Published in Cancer Weekly, July 26th, 2005
"Acquired mutations in the hematopoietic transcription factor GATA binding protein-1 (GATA1) are found in megakaryoblasts from nearly all individuals with Down syndrome with transient myeloproliferative disorder (TMD, also called transient leukemia) and the related acute megakaryoblastic leukemia (DS-AMKL, also called DS-AML M7)," scientists in the United States report.
"These mutations lead to production of a variant GATA1 protein (GATA1s) that is truncated at its N terminus," said Z. Li and colleagues, Children's Hospital.
"To understand the biological...
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Source: Cancer Weekly (2005-07-26)
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