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Radiotherapy

Radiation-induced apoptosis preceded the delayed apoptosis of CGL1 hybrid cells

Published in Cancer Weekly, July 26th, 2005

A radiation-induced acute apoptosis preceded the delayed apoptosis and neoplastic transformation of HeLa X fibroblast (CGL1) human hybrid cells.

"Exposing CGL1 hybrid cells to 7 Gy of X rays results in the onset of a delayed apoptosis in the progeny of the cells 10 to 12 cell divisions postirradiation that correlates with the emergence of neoplastically transformed foci. The delayed apoptosis begins around day 8 postirradiation and lasts for 11 days," investigators in the United States reported.

"We now demonstrate that the delayed apoptosis is also characterized by the appearance of approximately 50-kb apoptotic DNA fragments and caspase 3...

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