Cancer Therapy
Induced p14ARF drives p53-dependent cell cycle arrest but not apoptosis
Published in Cancer Weekly, July 26th, 2005
According to a study from Australia, "expression of the p14ARF tumor suppressor is induced by hyperproliferative signals produced by RAS, MYC and other oncogenes. p14ARF quenches inappropriate mitogenic signaling by activating the p53 pathway, and the frequent loss of p14ARF in human cancer diminishes the duration and level of the p53 response."
"Consistent with this role, p14ARF accumulation can induce potent cell cycle arrest, but its role in promoting apoptosis has not been well established," said S. Gallagher and colleagues, University of Sydney.
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Source: Cancer Weekly (2005-07-26)
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