Colorectal Cancer

Alterations in tissue inhibitor of TIMP-3 implicated in colorectal tumors

Published in Cancer Weekly, July 26th, 2005

Alterations in the tissue inhibitor of metalloproteinase-3 (TIMP-3) were implicated in human colorectal tumors.

"Methylation of promoter regions and frameshift mutations in microsatellites of the coding sequence (CDs) of genes are frequently associated with loss of expression in microsatellite instable (MSI) colorectal carcinoma. In a panel of 40 MSI and 24 microsatellite stable (MSS) colorectal tumors, as well as 6 cultured colorectal carcinoma cell lines, hypermethylation of the TIMP3-promoter was found in 28% of MSI and 25% of MSS tumors, respectively," investigators in Germany reported.

"Additionally, 3 MSI tumors and 1 cell line displayed...

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Source: Cancer Weekly (2005-07-26)

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