Oncology
Standard cancer therapy activates vectors with synthetic gene promoters
Published in Cancer Weekly, August 2nd, 2005
"Combining gene therapy with radiotherapy and chemotherapy holds potential to increase the efficacy of cancer treatment, while minimizing side effects. We tested the responsiveness of synthetic gene promoters containing CArG elements from the early growth response 1 (Egr1) gene after neutron irradiation, doxorubicin, and cisplatin," investigators in the United States report.
"Human MCF-7 breast adenocarcinoma and U373-MG glioblastoma cells were transfected with plasmids containing CArG promoters controlling the expression of the green fluorescent protein (GFP). Exposing the...
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Source: Cancer Weekly (2005-08-02)
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