Vector Development
Patient-specific factors dictate the infectivity of HSV-1 amplicon vectors
Published in Cancer Weekly, August 2nd, 2005
According to researchers in Germany, "we investigated the variability in infectivity of cells in primary brain tumor samples from different patients using an herpes simplex virus (HSV)-1 amplicon vector. We studied the infectivity of HSV-1 amplicon vectors in tumor samples derived from neurosurgical resections of 20 patients."
"Cells were infected with a definite amount of HSV-1 amplicon vector HSV-GFP. Transduction efficiency in primary tumor cell cultures was compared to an established human glioma line. Moreover, duration of transgene expression was monitored in different...
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Source: Cancer Weekly (2005-08-02)
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