Breast Cancer
Oncogene activation in tumor cells may be the result of secondary factors
Published in Cancer Weekly, August 2nd, 2005
"Although the cell line MCF7 is widely used in breast cancer research, its cytogenetic properties have not been thoroughly investigated so far. As conventional G-banding analysis cannot resolve the complex chromosome aberrations, we investigated MCF7 cells using molecular-cytogenetic methods, with particular attention to the DNA amplification site on chromosome 20q," investigators in Germany report.
"With spectral karyotyping we found numerous unbalanced chromosome translocations, and with comparative genomic hybridization we detected many quantitative genomic imbalances,"...
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Source: Cancer Weekly (2005-08-02)
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