Oral Carcinogenesis

Caspase 6 implicated as a tumor suppressor gene

Published in Cancer Weekly, August 2nd, 2005

Caspase 6 was highlighted as a putative tumor suppressor gene.

According to recent research from Japan, "We analyzed the loss of heterozygosity of the long arm of chromosome 4 in 40 oral cancers, using 16 microsatellite markers based on data from the human genome sequence, and defined the deletional mapping of the region with putative tumor suppressor genes. Our data revealed two distinct commonly deleted regions around the markers, D4S2623 and D4S1644, with an allelic deletion of 44 and 39%, respectively."

"Additional mapping and use of the markers near one of these hot spots narrowed down the minimally deleted region about 1.5 Mbp around the...

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Source: Cancer Weekly (2005-08-02)

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