Astrocytoma

Cathepsin D suggested as potential marker for poor prognosis in glioma patients

Published in Cancer Weekly, August 9th, 2005

Scientists proposed that cathepsin D could be used as potential serum marker for poor prognosis in glioma patients.

According to a study from Japan, "Cathepsin D is an aspartyl protease involved in protein catabolism and tissue remodeling which can be secreted from cancer cells. To identify a potential serum marker for gliomas, we investigated the gene expression levels of cathepsin D in 87 tissue samples and measured the protein concentrations in sera of glioma patients."

"The tissue samples consisted of 43 glioblastomas, 13 anaplastic astrocytomas, 22 astrocytomas, and 9 normal brain tissues. The results of real-time quantitative reverse...

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Source: Cancer Weekly (2005-08-09)

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