Cancer Weekly

Gene Silencing - RNA interference elicits tumor response despite hypoxia-induced VEGF-A

Gene Silencing - Researchers target the transcription start site of DNA

Gene Therapy - Enhanced CD20 expression in tumor B cells controlled by ERK-dependent mechanisms

Gene Transfer - SART-1 gene transduction causes cellular destruction

Generic Drugs - U.S. FDA approves packaging for multi-dose generic Carboplatin

Glioblastoma - Radiotherapy found effective in patients with glioblastoma multiforme

HAM/TSP Pathogenesis - Interferon-beta 1a affects immune mechanisms central to HAM/TSP pathogenesis

HIV/AIDS Research - Enrollment complete in phase 1 trial of PRO 140

HIV/AIDS Research - Phase IIb sudy shows Reverset trial results reported

HIV/AIDS Therapy - Study shows effectiveness of protease inhibitor in AIDS treatment

HIV/AIDS-Related Kaposi Sarcoma - HAART plus liposomal doxorubicin induces tumor remission in HIV-related KS

Head & Neck Cancer - Paclitaxel, cisplatin, 5-fluorouracil and radiotherapy managed SCC

Hematology - Genetically modified natural killer cells overcome HLA-mediated resistance

Hematology - Hematologic follow-up recommended for patients treated with radioiodine

Hepatic Resection - Novel ultrasound-directed technique used in major hepatic resections

Hepatitis C Virus - Company initiates phase Ib study of GI-5005 for chronic hepatitis C infection

Hepatocellular Cancer - Sirolimus improves the survival of patients transplanted for liver cancer

Hepatocellular Carcinoma - Interferon prevents liver cancer in chronic hepatitis C non-responders

Hepatocellular Carcinoma - Lipogenic enzymes proliferate in primary liver cancer

Hepatocellular Carcinoma - Risk factors associated with bile leakage after hepatic resection

Hepatoma - Transforming growth factor beta mediated apoptosis in human hepatoma cells

Hodgkin Lymphoma - An unusual presentation of Hodgkin lymphoma reported

Human Papillomavirus - Anti-sera against L2 neutralized papillomavirus types

Human Papillomavirus - HPV produced independently of viral replication

Human Papillomavirus - HPV-like particles stabilized by non-ionic surfactants

Human Papillomavirus Vaccine - Anti-papillomavirus vaccines and prevention of cervical cancer reviewed

Imaging - Electronics company and RaySearch Laboratories expand strategic relationship

Imaging - Entities plan cooperative efforts in medical imaging, diagnostics, therapy

Imaging - MR spectroscopy helps identify cancerous breast tumors, study authors report

Imaging - Quantum dots programmed to glow in presence of enzyme activity

Imidazole - Iodinated nitroimidazoles used as radiosensitizers

Immunotherapy - GCAN 101 trial underway

Infection - Gonococci studied, effect on carcinoembryonic antigen-expressing B cells shown

Influenza Vaccine - Two influenza vaccine doses do not improve response in cancer patients

Information Technology - IT company introduces new version of radiotherapy treatment planning software

Kidney Cancer - Distance to normal renal parenchyma in NSS did not affect survival

Kidney Cancer - Gene therapy designed to seek VHL mutations may benefit renal cancer patients

Leukemia - Amino acid concentrations in cerebrospinal fluid measured in ALL children

Leukemia - Blood stem cell transplant from a relative better option for children

Leukemia - Children do not show increased susceptibility for developing secondary AML

Leukemia - Fecal fungal flora of immunosuppressed patients studied

Leukemia - Glycated fibrinogen-methotrexate conjugates showed antileukemic activity

Leukemia - Intrathecal chemotherapy evaluated in children with acute leukemia

Leukemia - MLL fusion proteins suppressed p53-mediated response to DNA damage

Leukemia - Study of unrelated bone marrow transplantation for leukemia serves as benchmark

Liver Cancer - Dynamin 2 interactions let radiation send adenoviruses into liver cells

Liver Cancer - Microwave tissue coagulation yields acceptable results in resected livers

Liver Cancer - New findings in liver cancer described

Liver Cancer - Researchers discover link between viral infection and liver cancer

Liver Neoplasm - Bilirubin level fluctuation after hepatectomies justified drain maintenance

Liver Transplantation - Artificial neural network and genotyping predict liver cancer recurrence

Lung Cancer - Accelerated radiotherapy scheme used to treat NSCLC

Lung Cancer - Acute esophageal toxicity detected in NSCLC cancer patients after radiotherapy

Lung Cancer - Building a better mouse model of lung cancer: Fhit counts

Lung Cancer - Current approaches in chemotherapy of advanced and metastatic NSCLC detailed

Lung Cancer - Lung cancer diagnosed with low-dose helical CT

Lung Cancer - Lung cancer incidence increasing in Sardinia

Lung Cancer - Novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis

Lung Cancer - Relationship between charcoal cigarette filters and lung cancer risk evaluated

Lymphoma - MTAP gene silenced by promoter hypermethylation in lymphoma cells

Lymphoma Vaccine - Intratumoral injection of naive dendritic cells effective for lymphoma

Lymphoma Vaccine - Tumor-derived idiotype vaccine for non-Hodgkin's lymphomas described

MALT Lymphoma - Clinical features of Helicobacter heilmannii infection studied

Marketing - Market report indicates makers of lung cancer drugs spend $38 million on launch

Medical Devices - Immunicon announces quality system certification

Medical Devices - Vortex EX and Vortex EX Max infusion ports introduced

Melanoma - Outcomes after cervical lymph node dissection evaluated

Melanoma - Relation of cutaneous, ocular, and visceral melanoma to ethnicity analyzed

Melanoma - Saponins exhibited cytotoxic effect on human tumor cell lines

Melanoma Vaccine - Autoimmune toxicities linked to antitumor vaccines and low-dose IL-2

Melanoma Vaccine - Hybrid peptide enhances CD4+ T-cell response in DR4-transgenic mice

Melanoma Vaccine - Melanoma patients do not respond to plasmid DNA vaccine encoding MART-1

Melanoma Vaccines - Findings advance knowledge in melanoma vaccines research

Mergers & Acquisitions - Healthcare Technologies signs agreement for the acquisition of Immvarx, Inc.

Mergers & Acquisitions - Israeli generic drug company to acquire IVAX Corporation for $7.4 billion

Mesothelioma - Cases of localized malignant mesothelioma discussed

Metastasis - Cornell researcher uncovers details of how cancer spreads

Metastasis - New understanding of cell movement may yield ways to brake cancer's spread

Morbid Obesity - Perineal prostatectomy useful for prostate cancer in morbid obesity

Multidrug Resistant - Carbapenem use {{>=}}7 days risks multidrug resistant to P. aeruginosa

Multiple Myeloma - COX-2 is an independent predictor of poor outcome in multiple myeloma

Multiple Myeloma - Cancer-testis antigens correlate with plasma-cell proliferation

Musculoskeletal Tumors - Usefulness and limitations of ultrasound-guided core biopsy assessed

Mycosis Fungoides - Therapeutic approach to mycosis fungoides and Sezary syndrome addressed

Myeloma - Case of reactive plasmacytosis mimicking multiple myeloma found in pSS patient

Nasal Cancer - Dosimetric and clinical results of 3D CRT for nasopharyngeal carcinoma revealed

Neuroblastoma - Customized gene chip rapidly detects genetic changes in childhood cancer

Non-Hodgkin Lymphoma - Data safety monitoring board recommends continuation of MyVax phase III trial

Non-Hodgkin Lymphoma - Risk of non-Hodgkin lymphoma associated with occupational exposure

Ocular Cancer - New treatment for ocular tumors using membrane FasL vesicles developed

Oncogenesis - New findings in oncogenesis described

Oncology - Heparanase helps establish cancer metastasis to the bone

Oncology - Low VEGF levels may indicate lung cancer's response to gefitinib

Oncology - Mathematical model predicts effect of acidity on tumor growth

Oncology - Microvascular density predicts the survival of bladder cancer patients

Oncology - Oblimersen enhances the antitumor effects of gimatecan in melanoma xenografts

Oncology - Recent findings illuminate research in oncology

Oncology - Securin is a biomarker for breast cancer invasion

Oral Cancers - Chemiluminescence aided in detection of oral cancer and epithelial lesions

Oral Health - Salivary pleomorphic adenomas produce a number of VEGF splicing forms

Otorhinolaryngology - Use of anterolateral thigh flaps to reconstruct head and neck defects evaluated

Ovarian Cancer - Chemotherapy affected mutation frequency of ovarian cancer cells

Ovarian Cancer - Relation of androgens and receptors to ovarian cancer risk analyzed

Pamidronate - Pamidronate and 1,24(S)-dihydroxyvitamin D-2 inhibited growth of cancer cells

Pancreatic Cancer - Current diagnosis and treatment of pancreatic cancer in China reported

Pancreatic Cancer - New treatment modalities for pancreatic adenocarcinoma needed

Pancreatic Cancer - Older Americans with new-onset diabetes have high risk of pancreatic cancer

Pancreatic Cancer - Osteoclast-like giant cell tumor of pancreas with ductal adenocarcinoma examined

Pancreatic Ductal Carcinoma - Factors predicting recurrence after pancreatic ductal carcinoma resection listed

Panduratin A - Panduratin A induced apoptosis in human colon cancer HT-29 cells

Patient Follow-Up - Telephone follow-up experiences at Rapid Response Radiotherapy Program shared

Pediatric Radiology - Ambient Experience radiology suite opens at Illinois children's hospital

Personnel - Alan M. Solinger, MD, named clinical immunology VP by biopharmaceutical company

Personnel - Cancer therapeutics developer names Rotherham, Myers to executive positions

Personnel - Diagnostic test company names experienced U.S. diagnostics executive to head R&D

Personnel - Diagnostics company names Monte W. Wiltse vice president of sales and marketing

Personnel - Genomics-based drug-discovery company names Ian D. Malcolm VP

Personnel - James Smith named COO by manufacturer of biopsy, tissue excision products

Personnel - Lewis C. Cantley, PhD, named to pharmaceuticals scientific advisory board

Personnel - Thomas A. Davis, MD named chief medical officer; to lead clinical development

Pharmaceutical Research - Improved RNA amplification garners more cells for cancer vaccines

Photomedicine - Hypericin enacts a multifocal attack on angiogenesis when kept in the dark

Product Licensing - Florida medical school signs license agreement for coenzyme with holding company

Product Licensing - Pharma company enters license agreement with Lavipharm Laboratories

Prognostics - CT scans predicted weight of Wilms tumor

Prostate Cancer - AMACR expression altered in prostatic adenocarcinoma following hormone therapy

Prostate Cancer - AMACR expression is significantly associated with prostate cancer

Prostate Cancer - Adenocarcinoma of the prostate discussed

Prostate Cancer - Anticancer mechanism arrests early prostate cancer

Prostate Cancer - Concept of hormone therapy in metastatic prostate cancer reappraised

Prostate Cancer - External beam radiotherapy used as curative treatment of prostate cancer

Prostate Cancer - Findings describe new data in prostate cancer research

Prostate Cancer - Maintaining lifestyle top of men's list when choosing a prostate cancer therapy

Prostate Cancer - Omega-6 fatty acids cause prostate tumor cell growth in culture

Prostate Cancer - PSA level measured after high-dose radiotherapy of localized prostate cancer

Prostate Cancer - Phase III Trial: Provenge extends survival in advanced prostate cancer patients

Prostate Cancer - Predictors of prostate cancer screening among health fair participants assessed

Prostate Cancer - Predictors of response in patients to salvage radiotherapy assessed

Prostate Cancer - Prostate cancer incidence in Guadeloupe estimated

Prostate Cancer - Reasonable delay of surgical treatment in men did not impact prognosis

Prostate Cancer - Trial of ozarelix in patients with hormone-dependent prostate cancer initiated

Prostate Cancer Vaccine - CTL-directed peptides spread immune response to PSA protein

Prostate Cancer Vaccine - Monitoring in trial of prostate-specific antigen DNA vaccine reported

Prostatitis - Diagnosis of nonspecific granulomatous prostatitis analyzed

Protease Inhibitors - Cytotoxic T lymphocytes analyzed, regulatory aspects clarified

Proteomics - Protein-protein interactions in cancer detailed

Proteomics - Research in proteomics provides new insights

Public Health - Association between primary care and health outcomes in cities is complex

Radiation Mutagenesis - NBS1 deficiency increased ionizing radiation mutagenesis

Radiation Therapy - DNA repair genes make lung cancer cells resist radiotherapy

Radiation Therapy - Data: Electronic brachytherapy accurately delivers nonradioactive radiation

Radiation Therapy - Novel algorithm reduces CT metal artifacts during treatment planning

Radiation Therapy - Risk of CV mortality after irradiation for childhood cancer is increased

Receptors - Neuropeptide receptors examined, expression in neuroblastoma cells clarified

Rectal Cancer - Digital fusion imaging diagnosed local recurrence of rectal cancer

Rectal Cancer - Hydronephrosis used as prognostic factor in pelvic recurrence from rectal cancer

Rectal Cancer - Local staging of rectal carcinoma discussed

Rectal Cancer - Long-term anorectal dysfunction occurred after postoperative radiotherapy

Rectal Cancer - Role of CEA and CA 19-9 in adjuvant radiochemotherapy assessed

Renal Cell Carcinoma - Platelet-derived growth factor blockade stops kidney cancer progression

Retinoblastoma - Neurokinin-1-receptor antagonist acted as antitumoral agent on retinoblastoma

Salivary Glands - Intraoral minor salivary gland tumors characterized

Salivary Glands - Pleomorphic adenoma of the salivary glands analyzed

Salivary Glands - Salivary gland tumors studied in a Brazilian population

Sarcomas - Mechanisms of sarcomagenesis analyzed

Sarcomas - Sarcoma management in adolescents and young adults reported

Sinonasal Tumors - Endoscopic management of sinonasal tumors discussed

Skin Cancer - Is melanoma being overdiagnosed in the United States?

Skin Cancer - Primitive nonneural granular cell tumors of skin analyzed clinicopathologically

Skin Grafting - Principles of plastic reconstruction for advanced carcinoma of eyelids discussed

Squamous Cell Carcinoma - Factors affecting survival in patients with oral cancer described

Stem Cell Research - Postnatal muscle-derived stem cells have extra capacity for self-renewal

Stem Cell Transplantation - CD133+ SCs used for haploidentically mismatched peripheral blood SCT

Stem Cell Transplantation - Fibrinolytic test findings may facilitate early VOD diagnosis in pediatric HSCT

Stem Cell Transplantation - High-dose cyclophosphamide effective for refractory MM after SCT relapse

Stem Cell Transplantation - New research in the area of stem cell transplantation detailed

Stem Cell Transplantation - Reduced-intensity SCT successful in malignant lymphoma/ileostomy patient

Stomach Cancer - Methylenetetrahydrofolate reductase implicated in risk of stomach cancer

Thyroid Gland - MIB-1 compared with topoisomerase II-alpha immunostaining

Thyroid Gland - Minimum follow-up time required for estimation of cure rate of cancer patients

Tissue Engineering - Tissue engineering for airway reconstruction avoids tracheotomy

Tuberculosis - Short-course chemotherapy safe/effective in pediatric respiratory tuberculosis

Tumor Suppression - Interleukin-12 immunotherapy hastens the demise of solid tumors

Vaccine Development - Method to rapidly assess antigen-specific T-cell response developed