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Neuroblastoma

Customized gene chip rapidly detects genetic changes in childhood cancer

Published in Cancer Weekly, August 23rd, 2005

Genetics researchers have developed a customized gene chip to rapidly scan tumor samples for specific DNA changes that offer clues to prognosis in cases of neuroblastoma, a common form of children's cancer.

Rather than covering the entire genome, the microarray focuses on suspect regions of chromosomes for signs of deleted genetic material known to play a role in the cancer.

The investigators, from the Children's Hospital of Philadelphia and Thomas Jefferson University, said their technique may be readily adapted for other types of cancer. The proof-of-principle study appears in the August 2005 issue of Genome Research.

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