Published in Cancer Weekly, August 30th, 2005
"Imatinib mesylate (IM) was introduced in chronic myeloid leukemia (CML) treatment in the late 1990s and substantially changed the therapeutic approach to the disease, by inducing complete cytogenetic response (CCR) in approximately 60% of cases. Nevertheless, some concerns exist about the duration of response to treatment and the onset of resistance to IM," researchers in Italy report.
"Twenty-five chronic-phase CML patients in stable CCR (>6 months) treated for at least 1 year with IM at the standard dose (400 mg/day) were mobilized with recombinant human...
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