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Adhesion

Integrin-mediated adhesion analyzed, phospholipase action defined

Published in Cancer Weekly, September 6th, 2005

According to recently published research from England, phospholipase D2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-inase Igamma b.

"Cellular adhesion can be regulated by, as yet, poorly defined intracellular signalling events. Phospholipase D enzymes generate the messenger lipid phosphatidate and here we demonstrate that suppression of this reaction inhibits cellular adhesion," wrote D.J. Powner and colleagues, University of Birmingham.

"This effect was reversed by the addition of cell-permeable analogues of either phosphatidate or phosphatidylinositol 4,5-bisphosphate. By contrast, neither diacylglycerol nor...

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