Acute Myeloid Leukemia
AML bearing cytoplasmic nucleophosmin showed distinct gene expression profile
Published in Cancer Weekly, September 6th, 2005
According to a study from Italy, "Approximately one third of AMLs are characterized by aberrant cytoplasmic localization of NPMc+ AML, consequent to mutations in the NPM putative nucleolar localization signal. These events are mutually exclusive with the major AML-associated chromosomal rearrangements, and are frequently associated with normal karyotype, FLT3 mutations, and multilineage involvement."
"We report the gene expression profiles of 78 de novo AMLs (72 with normal karyotype; 6 without major chromosomal...
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Source: Cancer Weekly (2005-09-06)
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