Lymphoma
IgV H mutations in mantle cell lymphoma prognosticated more favorable outcome
Published in Cancer Weekly, September 13th, 2005
"MCL is associated with a very unfavorable clinical course. This is particularly true for mantle cell lymphoma of the blastoid subtype (MCL-b)," scientists in Switzerland reported.
"In order to define prognostic factors, we analyzed the impact of IgV H gene somatic hypermutations on clinical outcome in a series of 21 cases of morphologically, phenotypically, and genotypically well-characterized MCL-b. Testing and estimation were performed using log-rank statistics and displayed on Kaplan-Meier graphs....
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Source: Cancer Weekly (2005-09-13)
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