Leukemia

Wnt16 inhibition induced apoptosis in ALL cells

Published in Cancer Weekly, September 20th, 2005

Wnt16 inhibition induced apoptosis in acute lymphoblastoid leukemia (ALL) cells.

"The Wnt family of secreted glycoproteins is widely involved in cell proliferation, differentiation and oncogenesis. Many Wnt signaling genes are upregulated and activated in chronic lymphocytic leukemia," researchers in the United States reported.

"Less is known concerning acute leukemia. One subtype of ALL is characterized by a t(1;19) chromosomal translocation resulting in a fusion protein E2A-Pbx1 that promotes transformation and leukemogenesis. Wnt16 has been shown to be targeted by E2A-Pbx1," explained J. Mazieres and colleagues, UCSF Comprehensive Cancer...

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Source: Cancer Weekly (2005-09-20)

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