Drug Delivery

Intratumoral injection of BCNU in ethanol resulted in enhanced delivery to tumor

Published in Cancer Weekly, September 20th, 2005

Scientists claimed that intratumoral injection of 1,3-bis-chlorethyl-1-nitrosourea (BCNU) in ethanol (DTI-015) resulted in enhanced delivery to tumors.

According to a study from the United States, "Solvent facilitated perfusion (SFP) has been proposed as a technique to increase the delivery of chemotherapeutic agents to tumors. SFP entails direct injection of the agent into the tumor in a water-miscible organic solvent, and because the solvent moves easily through both aqueous solutions and cellular membranes it drives the penetration of the solubilized anticancer agent throughout the tumor."

"To test this hypothesis, we compared the pharmacokinetics...

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Source: Cancer Weekly (2005-09-20)

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