Vaccine Adjuvant

Neem leaf extract acts as adjuvant for B16 melanoma surface antigen

Published in Cancer Weekly, September 20th, 2005

Immunostimulatory neem leaf preparation acts as an adjuvant to enhance the efficacy of poorly immunogenic B16 melanoma surface antigen vaccine.

According to a study from India, "Immunogenicity of the poorly immunogenic B16 melanoma cell surface antigen (B16MelSAg) was enhanced by combining B16MelSAg with NLP in C57BL/6 mice, as evidenced by ELISA and flow cytometry. NLP was as effective as Freund's complete and incomplete adjuvant to generate antibodies recognizing the B16MelSAg. The NLP generated antibody was a gamma globulin with a subtype of IgG1."

"Splenic lymphocytes from B16MelSAg+NLP treated mice proliferated more rapidly in vitro when...

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Source: Cancer Weekly (2005-09-20)

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