Published in Cancer Weekly, September 20th, 2005
"Common polymorphisms in genes that affect estrogen levels may be associated with breast cancer risk." Scientists from the United States investigated the associations between breast cancer and sequence variants in several genes in the estradiol/estrone metabolism pathway (CYP1A1*2A, CYP1A2*1F, CYP1B1 Leu432 Val, CYP3A4*1B, COMT Val158 Met, SULT1A1Arg213 His) as well as the Arg554 Lys variant in AHR (a transcription factor for CYP1A1, CYP1A2, and CYP1B1) in a case-control study of 1,339 breast cancer cases and 1,370 controls...
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