Breast Cancer Risk Factors

Estrogen metabolism-related genes and breast cancer risk studied

Published in Cancer Weekly, September 20th, 2005

The relationship between estrogen metabolism-related genes and breast cancer risk was recently studied.

"Common polymorphisms in genes that affect estrogen levels may be associated with breast cancer risk." Scientists from the United States investigated the associations between breast cancer and sequence variants in several genes in the estradiol/estrone metabolism pathway (CYP1A1*2A, CYP1A2*1F, CYP1B1 Leu₄₃₂ Val, CYP3A4*1B, COMT Val₁₅₈ Met, SULT1A1Arg₂₁₃ His) as well as the Arg₅₅₄ Lys variant in AHR (a transcription factor for CYP1A1, CYP1A2, and CYP1B1) in a case-control study of 1,339 breast cancer cases and 1,370 controls...

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Source: Cancer Weekly (2005-09-20)

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