Cancer Therapy

Alendronate may control cancers propelled by new vessel growth

Published in Cancer Weekly, September 27th, 2005

Alendronate may control cancers propelled by new vessel growth.

"There is increasing evidence that bisphosphonates have direct antitumor effects in vivo in addition, to their therapeutic antiresorptive properties. Bisphosphonates inhibit proliferation and induce apoptosis of many cancer cell lines," scientists in France report.

"They also exhibit anti-invasive properties in vitro and in vivo. We have previously shown that a novel non-nitrogen-containing bisphosphonate inhibited tumor growth of A431 human epidermoid carcinoma cells. In the present study, we investigated the antitumor properties of three nitrogen-containing bisphosphonates on A431...

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Source: Cancer Weekly (2005-09-27)

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