Cancer Weekly

Drug Development - Pharmaceutical company selects small molecule oncology drug for clinical study

Drug Development - Phase II trial initiated for Fodosine in chronic lymphocytic leukemia

Drug Research - Bioactivity of biflorin evaluated

Drug Resistance - Proton pump inhibitors reduced tumor resistance

Endocrinology - Management of I-131 therapy for thyroid cancer discussed

Endomentrial Cancer - Flavopiridol used as second-line chemotherapy of endometrial carcinoma

Environmental Health - Children sensitized to electromagnetic fields

Environmental Health - Cigarette smoking led to higher mortality due to stomach cancer

Environmental Health - Genotoxic effects examined for nurses handling antineoplastic drugs

Environmental Health - Pesticide exposure in agricultural population of Costa Rica assessed

Epidemiology - Atlas of cancer in India developed

Epidemiology - Epidemiology of bile duct and gallbladder cancer discussed

Epidemiology - Mortality and incidence rates of stomach cancer in the JACC Study reviewed

Esophageal Cancer - A second malignancy deemed major cause of death among esophageal cancer patients

Esophageal Cancer - Intrathoracic gastric emptying of solid food after esophagectomy studied

Esophageal Cancer - Outcomes of tracheobronchial stents in patients with airway disease reviewed

Finance - Monoclonal antibody development company raises $13.9 million in financing

Finance - Oncology-focused drug development company reports strong cash balance to June 30

Finance - Radiation therapy products provider reports revenues of $8.1 million

Gallbladder Cancer - Strategies for surgical treatment of gallbladder cancer discussed

Gastric Cancer - Gastric cancer sensitivity to 5-FU/CDDP evaluated

Gastric Cancer - Synergistic interaction between oxaliplatin and SN-38 examined

Gastroenterology - Esophageal melanosis linked to squamous cell neoplasms in alcoholic Japanese men

Gastroenterology - Liposomal doxorubicin more effective in GI KS than in cutaneous AIDS-related KS

Gastroenterology - Mortality and morbidity after resection for AGEJ analyzed

Gene Research - Cancer gene MYC shown to activate gene involved in metastasis

Gene Research - Cytochrome P450 genes change as hepatitis C-related liver cancer progresses

Gene Research - Epigenetic activity silences Rb2/P130 gene in lung cancer, retinoblastoma cells

Gene Research - Expanding complexity of p53 discovered

Gene Research - Hepatitis B virus subtypes in African strains indicate stable variants

Gene Silencing - New findings in the area of gene silencing described

Genetics & Genomics - Genomic imbalances in leukemia and lymphoma detected by genomic hybridization

Genetics & Genomics - There is no single gene for aging

Genetics & Genomics - Treatment with ATRA reverses progression-related gene expression

Genital Cancer - Effect of cytoreductive surgery evaluated in ovarian metastasis

Genomics - Genetic counselors applaud task force's addressing of cancer genes screening

Graft-Versus-Host Disease Risk Factors - Early complete donor chimerism indicates risk of extensive GVHD

Gynecologic Cancer - Gynecological oncology organization president testifies in support of H.R. 1245

Gynecology - Hyaluronan may play a role in endometrial cancer progression

Gynecology - New research in the area of gynecology detailed

Gynecology - Outcomes after negative superficial inguinal lymphadenectomy reviewed

Head & Neck Cancer - Genes reveal lymph node micrometastasis in patients with oral cancer

Healthcare Coverage - Length of stay after open RRP reduced under guidance of clinical care pathway

Healthcare Coverage - Using navigators improved care of underserved patients

Hepatic Veno-Occlusive Disease - Defibrotide maker to commence phase III trial following discussions with FDA

Hepatocellular Cancer - Researchers publish new studies and findings in the area of hepatocellular cancer

Hepatology - Tumor doubling time predicts post-resection recurrence

Hormone Replacement Therapy - Postmenopausal hormone therapy increases breast cancer risk for all

Hurricane Relief - Leukemia society helps cancer patients in hurricane stricken areas

Imaging - Clinical treatments begin using On-board Imager in New Zealand

Imaging - New prostate MRI product released

Immunology - Coreceptor transcription analyzed, role of modulation revealed

Immunology - Host-residual invariant NK T cells attenuate graft-versus-host immunity

Information Technology - Complementary and alternative medicine information retrieved unintentionally

Information Technology - Moffitt Cancer Center opts for CipherTrust's e-mail security appliance

Information Technology - Web-based intelligent oncological nurse advisor announced

Kidney Cancer - Risk factors for kidney cancer in Japanese population revealed

Legal Issues - Attitudes toward writing advance directives surveyed

Leukemia - 2-Methoxyestradiol at low dose induced differentiation of myeloma cells

Leukemia - Acute myelogenous leukemia with tetrasomy 8 associated with poor prognosis

Leukemia - Breastfeeding patterns not linked to risk of childhood ALL

Leukemia - Expression of heat-shock proteins associated with poor prognosis in ALL

Leukemia - Therapeutic impact of epigenetic drugs on AML evaluated

Leukemia Vaccine Development - Receptor epitopes recognized by T cells of leukemia patients identified

Liposome Vaccine Development - PRA International helps complete BLP25 liposome vaccine phase III study

Liver Cancer - Reports describe recent advances in liver cancer research

Liver Transplantation - Living-donor liver transplantation suggested for hepatoblastoma

Lung Cancer - Carcinoembryonic antigen level in pleural lavage fluid determined prognosis

Lung Cancer - Comparisons made between mediastinal lymph-node dissection versus sampling

Lung Cancer - Data on the effectiveness of Onconase presented at conference

Lung Cancer - New findings in lung cancer described

Lung Cancer - Paper addresses new vector system in treatment of models of lung cancer

Lung Cancer - Phase 2 clinical trial of Xcytrin Injection initiated

Lung Cancer - Polymorphisms in DNA nucleotide excision repair genes linked to lung cancer risk

Lung Cancer - Radiation therapy potentiated effective oncolytic viral therapy

Managed Healthcare - Referrals to voluntary sector cancer day care center reviewed

Marketing - DTC ads address link between HPV and cervical cancer

Marketing - Makers of cancer therapies spend $85 million on marketing

Medical Devices - Accuracy of MRI in rectal cancer depended on location of the tumor

Melanoma - Data presented showing MDA-7/IL-24 controls growth of melanoma cells

Melanoma - Grant to help pharma company, Edith Cowen University identify melanoma gene

Melanoma - Positive data reported from phase II immunotherapy study in advanced melanoma

Melanoma Vaccine Development - Protection against melanoma found without autoimmune depigmentation

Melanoma Vaccines - Researchers describe findings in melanoma vaccines studies

Meningiomas - Tumor progression signs found absent in recurrences of resected meningiomas

Mergers & Acquisitions - EpiCept agrees to merger

Mergers & Acquisitions - M.D. Anderson acquires title to reserve centers

Metalloproteinase - Matrix metalloproteinases participate in osteosarcoma invasion

Metastasis - Classification of regional lymph node metastases from colon cancer reported

Metastasis - Predictors for patterns of brain relapse in NSCLC patients discussed

Metastasis - Pro GRP predicted incidence of brain metastasis in SCLC patients

Muscle Wasting - Positive clinical results and development plans for ostarine announced

Myelodysplastic Syndrome - Adequate cytogenetic examination in myelodysplastic syndromes outlined

Nanotechnology - Purdue scientists treat cancer with RNA nanotechnology

Natural Products - Lipoxygenase inhibitors from plant sources reviewed for medicinal value

Neurology - Endoscopic third ventriculostomy used to treat hydrocephalus

Neurology - Long-term outcome in patients harboring intracranial ependymoma estimated

Neurology - Management of head and neck plexiform neurofibromas discussed

Oncology - Ara-C fever and infections occurred after high-dose Ara-C treatment

Oncology - Biomarker denotes better outcomes for patients with esophageal cancer

Oncology - Growth factors bolster the metastatic phenotype of alveolar rhabdomyosarcoma

Oncology - Interferons have differential effects on liver cancer cell signals

Oncology - Research in oncology provides new insights

Ophthalmology - Loss of heterozygosity in Chinese sporadic retinoblastoma patients studied

Oral Cancer - Flavonoid glycosides inhibited oral cancer cell proliferation

Oral Cancer - Plasminogen activator/plasmin system suppressed cell-cell adhesion

Otorhinolaryngology - Methylation inactivates DAPK gene in laryngeal squamous cell cancer

Otorhinolaryngology - Rare tumors of internal auditory canal studied

Otorhinolaryngology - Ultrasonic glossectomy technique outlined

Ovarian Cancer - Barriers to effective communication with ovarian cancer patients identified

Ovarian Cancer - Breastfeeding and the risk of ovarian cancer investigated

Ovarian Cancer - New findings in ovarian cancer described

Ovarian Cancer - Psychological functioning in African American women at risk of cancer studied

Pain Management - Health Canada OKs Phase 2b trial of opioid inhalation formulation for acute pain

Pain Management - NDA filed for OraVescent fentanyl for management of cancer patients' pain

Pain Management - NSAIDs alone or with opioids evaluated as therapy for cancer pain

Pain Management - U.S. FDA approves marketing of sugar-free formulation of ACTIQ

Pancreatic Cancer - Combination of fluvastatin and gemcitabine prove effective tumor treatment

Pancreatic Cancer - Histone deacetylase inhibitors induced caspase-independent apoptosis

Pancreatic Cancer - Presence of PIF in urine did not predict malignancy of pancreatic tumor

Personnel - Dr. Ivan Horak named chief scientific officer of biopharma company

Personnel - Oncology group purchasing organization names vice president provider solutions

Personnel - Radiologist joins business development advisory board

Pharmaceutical Research - Consulting firm releases research on oncologists' perception and attitudes

Pharmaceutical Research - Lipid seocalcitol formulations have improved oral bioavailability

Prognostics - Prognostic relevance of molecular alterations in glioblastomas evaluated

Prostate Cancer - Efficacy of nurse-driven intervention examined in prostate cancer patients

Prostate Cancer - High prostate cancer mortality in Norway not influenced by Cancer Registry data

Prostate Cancer - High-dose radiation reduces risk of prostate cancer recurrence

Prostate Cancer - Interference with Hedgehog-Gli signaling inhibits prostate cancer

Prostate Cancer - Lifetime implications and cost-effectiveness of using finasteride estimated

Prostate Cancer - Microarray gene expression analysis detects prostate cancer genes

Prostate Cancer - PSA is still the best indicator of prostate cancer progression

Prostate Cancer - Phase I trial on OGX-011 completed

Prostate Cancer - Postoperative radiotherapy performed after radical prostatectomy

Prostate Cancer - Prostate cancer survivor/urologist launches screening program in Arizona

Prostate Cancer - Scientists study antioxidants' role in prostate cancer

Proteomics - Elevated expression of survivin-splice variants predicted poor outcome

Proteomics - Hepatitis B virus proteins yield clues about liver cancer formation

Proteomics - Studies add new findings to proteomics body of knowledge

Proteomics - Thioredoxin overexpression in HT-1080 cells induced senescence and sensitization

Radiation Therapy - Radiation therapy affected esophageal transit in breast tumor patients

Rectal Cancer - Patient surveillance examined after curative-intent surgery for rectal cancer

Rectal Cancer - Preoperative radiotherapy affected postoperative infective complications

Rectal Cancer - Retrorectal tumors present diagnostic and therapeutic challenges

Reproduction - Spermatocytes analyzed, recombination defects surveyed

Research Funding - Susan G. Komen Foundation awards more than $45 million to breast cancer research

Retinoic Acid - Retinoic acid stimulates proliferation of gastric epithelial progenitors

Rheumatoid Arthritis - Roche files first rheumatoid arthritis indication for MabThera in Europe

Skin Cancer - Prognostic guidance offered to physicians evaluating transplantation candidates

Skin Cancer - Radiotherapy replaced formal dissection after local excision of nodal disease

Skin Cancer - Study in Germany failed to change sun exposure and protective behavior

Skin Cancer - Sun exposure behaviors and knowledge among Chileans surveyed

Solid Cancers - GCS-100 achieves primary objective in phase I trial in advanced solid tumors

Stem Cell Research - Another step forward is taken in stem-cell research

Stem Cell Research - Polyamine depletion reduces TNFalpha/MG132-induced apoptosis in BM stromal cells

Stem Cell Research - Trafficking of normal SCs & metastasis of cancer SCs involve similar mechanisms

Stem Cell Transplant - Stem cell transplant survivors are as healthy as non-transplant patients

Stem Cell Transplantation - Aldehyde dehydrogenase activity is a marker for the quality of HSCT grafts

Stem Cell Transplantation - Allogeneic stem cell transplantation promising treatment for NK-cell neoplasms

Stem Cell Transplantation - Intensive GVHD prophylaxis required after unrelated-donor nonmyeloablative SCT

Stem Cell Transplantation - Low-dose methotrexate tolerable and effective for GVHD patients after AHSCT

Stem Cell Transplantation - Poor nutritional status prior to SCT associated with increased hospital stay

Stem Cell Transplantation - Single dose pegfilgrastim as safe and effective as daily filgrastim injections

Surgical Side Effects - Urinary bladder dysfunction after surgery assessed by residual urine volume

Surgical Technology - Alternative surgical approaches evaluated

Tamoxifen - Findings advance knowledge in tamoxifen research

Thoracic Surgery - Link between specialty training and mortality rates evaluated

Tissue Engineering - Bone marrow-derived fibroblasts recruited into fibrotic lesions

Tobacco Use - Cancer because Mom and Dad smoked?

Tobacco Use - Study finds childhood exposure to second hand smoke causes respiratory problems

Transplant Medicine - Reports describe recent advances in transplant medicine research

Trends - Cost pressures, reduced time to market drive demand for contract manufacturing

Trends - Update published on U.S. death rate and leading causes of death over 30 years

Tumorigenesis - Risk of tumorigenesis in overgrowth syndromes evaluated

Umbilical Cord Blood Transplantation - Number of nucleated cells infused most important predictor of success in UCBT

Virology - Findings in virology provide new insights

Weight Gain - Cisplatin chemotherapy increased risk of hypertension and weight gain