Drug Development

ELISA developed for pharmacological studies targeting HIF-1

Published in Cancer Weekly, October 11th, 2005

An enzyme-linked immunosorbent assay (ELISA) was developed for pharmacological studies targeting hypoxia-inducible factor 1 (HIF-1) alpha.

According to recent research published in the journal Clinical and Diagnostic Laboratory Immunology, "HIF-1 activates the transcription of a wide range of genes related to oxygen delivery and metabolic adaptation under hypoxic (low-oxygen) conditions. HIF-1 is, in fact, a heterodimer of two subunits, HIF-1 alpha and HIF-1 beta."

"The only analytical methods available for measuring HIF-1 alpha levels in tumors are immunohistochemistry and Western blotting. Immunohistochemistry has the advantage of allowing...

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Source: Cancer Weekly (2005-10-11)

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