Published in Cancer Weekly, October 11th, 2005
According to recent research published in the journal Clinical and Diagnostic Laboratory Immunology, "HIF-1 activates the transcription of a wide range of genes related to oxygen delivery and metabolic adaptation under hypoxic (low-oxygen) conditions. HIF-1 is, in fact, a heterodimer of two subunits, HIF-1 alpha and HIF-1 beta."
"The only analytical methods available for measuring HIF-1 alpha levels in tumors are immunohistochemistry and Western blotting. Immunohistochemistry has the advantage of allowing...
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