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Prostate Cancer

Active Stat5 predicts early recurrence

Published in Cancer Weekly, October 11th, 2005

The presence of activated Stat5 predicts early recurrence of prostate cancer.

"We have shown previously that the signal transducer and activator of transcription-5 (Stat5) is a critical survival factor in human prostate cancer cells," according to researchers in the United States.

"In addition, we recently showed that Stat5 is activated at a high level, particularly in high-grade human prostate cancers," added H.Z. Li and coauthors at Georgetown University. In a subsequent study, they "investigated whether activation of Stat5 in prostate cancer was linked to clinical outcome with disease recurrence as end point."

"Experimental...

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