Acute Lymphoblastic Leukemia
Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells
Published in Cancer Weekly, October 11th, 2005
According to a study from Italy, "The phosphatidyl-inositol 3 kinase (PI3k)/Akt pathway has been implicated in childhood acute lymphoblastic leukemia (ALL). Because rapamycin suppresses the oncogenic processes sustained by PI3k/Akt, we investigated whether rapamycin affects blast survival."
"We found that rapamycin induces apoptosis of blasts in 56% of the bone marrow samples analyzed. Using the PI3k inhibitor wortmannin, we show that the PI3k/Akt pathway is involved in blast survival. Moreover, rapamycin increased doxorubicin-induced apoptosis even in nonresponder...
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Source: Cancer Weekly (2005-10-11)
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