Published in Cancer Weekly, October 11th, 2005
According to recent research from the United States, "Activation of intracellular mitogenic signal transduction pathways driven by the ErbB family of receptor tyrosine kinases has been implicated in a variety of cancers. Amongst these, the tumorigenic roles of the epidermal growth factor receptor (EGFR) and HER-2 have been most extensively studied."
"Therapeutic antibodies and small molecule kinase inhibitors targeting EGFR have recently received regulatory agency approval for the treatment of colon and lung cancer, respectively. In this review, I briefly describe these agents and their...
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