Prostate Cancer Vaccine Development

Dendritic cells in prostate cancer not impaired in T-cell stimulation

Published in Cancer Weekly, October 18th, 2005

Dendritic cells generated from patients with androgen-independent prostate cancer are not impaired in migration and T-cell stimulation.

"Dendritic cell (DC)-based vaccination has been investigated as immunotherapy for several types of cancer. A potential drawback to vaccination with autologous monocyte-derived DCs (MoDCs) could be that MoDCs from patients are functionally impaired. In case of androgen-independent prostate cancer (CaP), the cancer itself, diverse prior therapies, and the hormone manipulation may affect the immune system," researchers in Switzerland report.

"MoDCs from patients suffering from androgen-independent CaP were generated...

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Source: Cancer Weekly (2005-10-18)

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